Earlier in 2000 to 2010 zidovudine, stavudine, nevirapine ,efavirenz and lopinavir -ritonavir were used to treat hiv.
But these drugs had lot of side effects like nausea vomiting ,anemia, muscle pains, skin reactions, dzziness.
Later tenofovir , Atazanavir and darunavir and dolutegravir have been used which were far better and effective with fewer side effects compared to the older drugs.
But even these drugs cause side effects like kidney and bone toxicity with tenofovir and diabetes and weight gain with dolutegravir .
So it is important to review with your treating physician periodically to monitor for these side effects and change the regimen accordingly